Phytother.Res 2012;26(10):1441-1448. , 43 volunteers with osteoarthritis used either a topical cream containing comfrey, tannic acid, and eucalyptus or a placebo cream 3x/ day for 6 weeks. Phytomedicine. New South Wales Health, Australia. Grube, B., Grunwald, J., Krug, L., and Staiger, C. Efficacy of a comfrey root (Symphyti offic. Like any new treatment, discontinue use if any irritation occurs. Do not use this product if you have a sensitivity to any of the ingredients. Herbal drugs and phytopharmaceuticals. Skip the missed dose if it is almost time for your next scheduled dose. They help us to understand how people use the website and give us the ability to provide targeted marketing to you. Its ready when the mixture has solidified somewhat and has a cloudy, creamy, and slightly runny consistency. After the tincture is made, then you can whip up the fabulous joint and muscle cream! 2004;154(21-22):498-507. Phytother Res. Journal of chiropractic medicine, 10(3), 147-156. https://doi.org/10.1016/j.jcm.2011.01.003, Stam, C., Bonnet, M. S., & van Haselen, R. A. 2013;21(6):724-745. doi:10.1016/j.ctim.2013.09.009. 2013;5(5):CD010538. Not all possible interactions are listed in this product guide. Cover, but leave a small air opening. Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Do not use this product without medical advice if you are breast-feeding a baby. Ulbricht, C. (2010). Aust.J Physiother. Complementary Health Approaches for Chronic Pain: What the Science Says. Many of those following the folk use of comfrey up to present-day think so. View abstract. Our associates are qualified to advise, visit us online or in store for unparalleled advice. We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. This is because only a small amount of the pyrrolizidine alkaloids are absorbed through the skin (. randomized double-blind study of 278 patients with fresh abrasions, a. topical preparation containing a 10% comfrey leaf extraction applied for 2-3 days reduced wound healing time of adults and children without side effects (Barna et al., 2012). First, make the comfrey root tincture by combining the dried comfrey root and alcohol in a sterilized, dry, glass pint jar. hollandandbarrett.com is a trading name of Holland & Barrett Retail Limited,. A symptomatic treatment of minor sprains and bruises. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: Results of a double-blind, randomised, placebo controlled, multicentre trial. Avoid comfrey with certain medical conditions, such as liver disease. Comfrey is traditionally used for the symptomatic treatment of minor sprains and bruises and is also known for its healing properties Customer Reviews Ingredients Full ingredients Brassica Campest is Seed Oil (Rapeseed Oil), Symphytum Officinale Herb (Comfrey Herb), BHA, Eucalyptus Globulus Leaf Oil (Eucalyptus Oil). Studies in humans are very limited. Company number 02758955 Registered VAT number 211727395. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. View abstract. 2013;163:5864 (2013) doi:10.1007/s10354-012-0162-4, Giannetti BM, Staiger C, Bulitta M, Predel HG. Stop using comfrey and call your healthcare provider at once if you have: liver problems-- nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). This site uses cookies to improve your experience. View abstract. Other prescription medicines that may harm the liver include: Some supplements may also harm the liver, including: It is essential to carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. Grube, B., Grnwald, J., Krug, L., & Staiger, C. (2007). Choose organically grown comfrey when possible. Comfrey contains toxic substances that cause liver damage, cancer, and death. Kucera, A., Barna, M., Holcova, S., Horacek, O., Hladikov, M., & Ottillinger, B. Instructions. Drug-induced liver injury. View abstract. View abstract. How do you use it and are there any side effects? This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. We go to great efforts to ensure that the information on this page is accurate at the time that the page was last edited. Using it no more than four to six weeks a year as a general guideline would be best. Some drugs increase how quickly the liver changes and breaks down comfrey. Topical comfrey is for use only on the skin. of India has issued Environment Impact Assessment EIA Notification dated 14th September, 2006 for according Environment Clearance(EC) to 8 categories of industries/projects by the Ministry of Environment & Forests, Govt. The study involved 43 patients with knee osteoarthritis and a six-week treatment period. View abstract. Food and Drug Administration. Comfrey. Phytomedicine, 11(6), 470-477. https://doi.org/10.1016/j.phymed.2004.02.001, Kucera, A., Barna, M., Holcova, S., Horacek, O., Hladikov, M., & Ottillinger, B. Mazzocchi, A. and Montanaro, F. Observational study of the use of Symphytum 5CH in the management of pain and swelling after dental implant surgery. Sometimes, massaging on topical ointments can help reduce pain and inflammation. Am J Med 1990;89:547-8. Shop buy 1 get 1 half price on all gut health products, Buy 1 get 1 Half Price | Plus an extra 20% off 25, App Exclusive | Get an extra 22% off 25 when you spend on the H&B App, Royal Mail strikes may cause a delay to our click and collect service, Looking for fitness advice & inspiration this New Year? Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Learn more in. Avila C, Breakspear I, Hawrelak J, Salmond S, Evans S. A systematic review and quality assessment of case reports of adverse events for borage (Borago officinalis), coltsfoot (Tussilago farfara) and comfrey (Symphytum officinale). Herbal medicine for low back pain: A Cochrane review. After the consistency begins to thicken, turn the mixer up a little bit. To make this recipe, first, you must prepare the comfrey root tincture. Browse our Sports Hub, Get 20% student discount with Student Beans, Discover the latest natural beauty products. Mosby Elsevier. Would you like to win our brilliant Botanical Business Package with nearly $1,000 in prizes? The use of babosa (Aloe vera) in treating burns: a literature review. It's typically only used in small amounts for a very short period. This includes androstenedione, bishop's weed, borage, chaparral, comfrey, DHEA, echinacea, garlic, germander, golden ragwort, hound's tongue, kava, licorice, niacin (vitamin B3), pennyroyal oil, red yeast, St. John's wort, and others. Regarding its antioxidant, antilipoperoxidant, antiinflammatory, and cytotoxic properties. After testing their 1000mg CBD oil drops for over a month, we now have little question this is the best CBD oil within the UK as of 2019. 4-4-2009;139(13-14):210-211. However, not a rate considered harmful for those with healthy livers.10,11, Masters Degree in Toxicology and BSc Hons in Medical Biochemistry. 2010;44(9):637-41. doi:10.1136/bjsm.2009.058677, Cameron M, Chrubasik S. Topical herbal therapies for treating osteoarthritis. Soaked foot in warm water with a few leaves of comfry. Set aside cup for the cream recipe and store the rest in a glass jar. We're proud to make a difference, and you can to. Comfreycontains PAs, substances that can cause significant damage, including: Therefore, it should never be taken by mouth. Registered VAT no. Bergamot oil is one of the most popular essential oils, but what is it & what are the benefits of using it? Study results revealed that pain intensity during active movement decreased an average of 95.2% in the group given comfrey ointment. Huxtable RJ, Awang DV. You may report side effects to FDA at 1-800-FDA-1088. Comfrey is a shrub that grows in parts of Europe, Asia, and North America. Researchers have found it does seem to reduce pain in some conditions, including back pain, osteoarthritis, and ankle sprains. A few studies show that comfrey cream may be helpful in the treatment of ankle sprains. Turn off heat and give it a good stir. ). 2016 Jan;41(2):116-33. doi:10.1097/01.brs.0000249525.70011.fe. Tanret, I. and Duh, D. [Pharmaceutical sheet. Set on a sunny windowsill and shake once a day for 2-4 weeks. Jurcu, R., & Jurcu, I. The participants were assigned three weeks of treatment with two grams of either comfrey ointment or a placebo three times a day. Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. British Homeopathic Journal, 90(01), 21-28. https://doi.org/10.1054/homp.1999.0460. Here's 10 things essential oils are great for. Although topical comfrey has been used for this indication, there's little evidence that it helps and can pose a big risk for nursing babies. Cochrane Database Syst Rev. A later study of 133 peoplefound some evidence that a topical combination of comfrey extract and tannic acid led to reduced knee pain. Simply massage into the skin as required. Comfrey's original name, knitbone, derives from the external use of poultices of its leaves and roots to heal burns, sprains, swelling, and bruises. Koll, R., Buhr, M., Dieter, R., Pabst, H., Predel, H. G., Petrowicz, O., & Staiger, C. (2004). Thus, it is not advised to ingest herbal preparations of comfrey unless guided by an expert pharmacologist and physician. Looks like you may need to upgrade your browser We're sorry, we no longer support the web browser that you are using At least three human studies found that the topical use of a cream containing comfrey root extract may safely help with pain, swelling, and mobility symptoms associated with an ankle sprain. Cbd Oil In Holland And Barrett. Palestrica of the Third Millennium Civilization & Sport. Comfrey has been cultivated as a green vegetable and has been used as an herbal medicine for more than 2,000 years. Smith, D. B., & Jacobson, B. H. (2011). Close LOGIN FOR DONATION. Wien Med Wochenschr. View abstract. Registered office: Samuel Ryder House, Barling Way, Eliot Park, Nuneaton, CV10 7RH, UK. Electric bowl mixer (like a KitchenAid) or a blender The roots and leaves of the comfrey plant have medicinal properties. 2010;44(9):637-641. Jedlinszki N, Balzs B, Csnyi E, Csupor D. Penetration of lycopsamine from a comfrey ointment through human epidermis. Therapeutic use of comfrey is limited because of its toxicity. (2018). Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. In a small study with 30 subjects, lower back pain from exercise was reduced with an ointment containing comfrey. British journal of sports medicine, 44(9), 637-641. https://doi.org/10.1136/bjsm.2009.058677, Grube, B., Grnwald, J., Krug, L., & Staiger, C. (2007). Gyorik, S. and Stricker, H. Severe pulmonary hypertension possibly due to pyrrolizidine alkaloids in polyphytotherapy. (2004). Ingesting cooking oil has been banned by the European Union, due to a high risk of liver toxicity.9, Adults with liver disease, cancer, or a history of alcoholism are also advised to avoid comfrey because the skin can also absorb the liver-damaging compounds. Comfrey has long been used in folk traditions for bruising and abrasions. In another study, participants with ankle sprains received either comfrey root extract cream or diclofenac gel, a nonsteroidal anti-inflammatory drug (NSAID). Electric bowl mixer (like a KitchenAid) or a blender, Small glass jars with lids for sharing (optional). Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Using a supplement like comfrey may have potential side effects. comfrey cream holland and barrett. The leaves and stems of comfrey contain pyrrolizidine alkaloids that can cause toxic damage if ingested in excess (Ulbricht, 2010). It is called knitbone or boneset, referring to the bone-like growth of its roots. Comfrey [Online article]. Comfrey can also contain echimidine, pyrrolizidine alkaloids (PAs), and symphytine, which can damage the liver, are carcinogenic (cancer-causing) and may harm a fetus. They help us to understand how people use the website and give us the ability to provide targeted marketing to you. Comfrey contains chemicals that cause serious liver damage when taken by mouth. MedlinePlus Medical Encyclopedia. Do not use extra comfrey to make up the missed dose. All Technology Jobs. We cover all you need to know in this article. Kucera, M., Barna, M., Horacek, O., Kalal, J., Kucera, A., and Hladikova, M. Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study. Safety Alerts & Advisories: FDA Advises Dietary Supplement Manufacturers to Remove Comfrey Products From the Market. All rights reserved. Consult with a licensed healthcare professional before using any herbal/health supplement. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. After the tincture is made, then you can whip up the fabulous joint and muscle cream! Acupuncture for Chronic Pain: Update of an Individual Patient Data Meta-Analysis. Vickers AJ, Vertosick EA, Lewith G, et al. (2001). Comfrey contains chemicals called. Many of those following the folk use of comfrey up to present-day think so. Proliferative and antioxidant activity of Symphytum officinale root extract. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. They help us to understand how people use the website and give us the ability to provide targeted marketing to you. It can grow up to 5 feet tall. Label with the ingredients and date made. However, further well-designed studies are needed. Pyrrolizidine poisoning. Sowa I, Paduch R, Strzemski M, et al. 4.3 4.3 out of 5 stars (225) $19.95 $ 19. Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. This is done by soaking the root in at least 50% alcohol for a minimum of two weeks. A member of the borage family, comfrey root, leaves, and stems have an obvious coat of bristly hair. Medicine makers would bind comfrey leaves and roots in poultices, then apply those poultices to the skin to treat injuries. Comfrey [Online article]. Those who used the comfrey ointment experienced improvements in pain, mobility, and quality of life. For External Use only Do not use if you are sensitive to any of the ingredients. Comfrey is traditionally used for the symptomatic treatment of minor sprains and bruises and is also known for its healing properties. Double boiler The Herbal Academy makes neither medical claim, nor intends to diagnose or treat medical conditions. Retrieved from, https://naturalmedicines.therapeuticresearch.com/databases/food,-herbs-supplements/professional.aspx?productid=295. The efficacy and safety of comfrey. Centurian, South Africa: Medpharm Scientific Publishers. Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: Results of a double-blind, randomised, placebo controlled, multicentre trial. Patients with hypersensitivity or allergic reactions to the plant should also avoid external use. As the consistency thickens some more, turn the mixer up a little bit more. Squish and squeeze as many leaves into as you can into the container. Comfrey may also be used for purposes not listed in this product guide. Penetration of lycopsamine from a comfrey ointment through human epidermis. Yield: Approximately 5 cups of whipped lotion. Regulatory Toxicology and Pharmacology, 83, 1-4. https://doi.org/10.1016/j.yrtph.2016.11.015. Koll R, Klingenburg S. [Therapeutic characteristance and tolerance of topical comfrey preparations. Store at room temperature away from moisture and heat. View abstract. Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have: Comfrey is considered likely unsafe to use during pregnancy. Dietary Supplements: What You Need to Know. This is not a complete list of side effects and others may occur. Finally, well warn of any side effects associated with comfrey oil. Learn more in The Comfrey Controversy: Can and Should One Use Comfrey Internally? After 2-4 weeks have passed, strain the root from the alcohol using a coffee filter inserted in a wire mesh strainer or similar setup. Limited trials have evaluated the effectiveness of alkaloid-free preparations for external use; however, these studies did not examine how much liver damage occurred in patients. This article discusses the uses and benefits of comfrey cream. (2018). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. about an hour two nites. Registered in England: company no. 2007;157(21-22):569-574. Wang YP, Yan J, Fu PP, Chou MW. Discontinue use if a rash appears. Please simply create an account before buying/booking any courses. Be sure to use comfrey root from a reputable source that has properly identified the species. J Ethnopharmacol 1995;48(2):61-76. 12 drops juniper berry (Juniperus communis) essential oil Generic name: comfrey [COM-free] Healthy adults: massage about 1 teaspoon of cream into a local area up to 4x/day for up to 2 weeks. Results of an observational study of patients]. Comfrey cream Do not take comfrey without medical advice if you are using any of the following medications: This list is not complete. View abstract. Acupuncture has also shown solid evidence of benefit for back pain. Many have said that it has helped them with a variety of aches and pains! We currently have no information for COMFREY overview. The groups using the herbal preparations reported a significantly greater reduction in pain and stiffness associated with osteoarthritis of the knee without serious adverse reactions (Smith & Jacobson, 2011). 2011;10(3):147-56. doi:10.1016/j.jcm.2011.01.003, Laslett LL, Quinn SJ, Darian-Smith E, et al. Its long, lance-shaped leaves can be up to 1 foot in length closer to the bottom of the stem and are shorter higher up the stem. Book your free, one-to-one online consultation with one of our qualified advisors. Comfrey cream combines ingredients like oils or water and glyceryl stearate with Symphytum officinale (comfrey) extracts. Efficacy of a comfrey root (Symphyti offic. WebMD does not provide medical advice, diagnosis or treatment. Copyright Holland & Barrett Limited 2023. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: Results of a randomized controlled clinical double-blind study. A handbook for practice on a scientific basis. What Happens If I Use Too Much Comfrey Cream? After 7 years in this role and a further year working as a drug safety officer in the pharmaceutical industry, Bhupesh joined Holland &Barrett as a Senior Regulatory Affairs Associate in 2019. In Western Europe, comfrey has been used topically for treating inflammatory disorders such as arthritis, gout, and thrombophlebitis, and internally for treating diarrhea. Store comfrey cream according to package instructions, typically at room temperature and out of reach of children and pets. The first European settlers of America considered comfrey so indispensable, they carried it on their journey across the Atlantic in the 1600s.2. By Megan Nunn, PharmD The Food and Drug Administration (FDA) released an advisory in July 2001 recommending that comfrey products be removed from the market because of cases of hepatic veno-occlusive disease. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Do not give any herbal/health supplement to a child without medical advice. Comfrey (Symphytum officinale) is a plant with yellow or purple flowers found in Europe, Asia, and North America. Topical preparations of comfrey are generally safe provided they are not applied excessively or to an open wound. Wien.Med.Wochenschr. 12 drops black pepper (Piper nigrum) essential oil Kuera, M., Barna, M., Horek, O., Kovrikov, J., & Kuera, A. Comfrey is often sold as an herbal supplement. Barna, M., Kucera, A., Hladikova, M., & Kucera, M. (2012). Other drugs may interact with comfrey, including prescription and over-the-counter medicines, vitamins, and herbal products. The chemicals contained in comfrey may cause birth defects. Osteoarthritis Cartilage. Comfrey oil shouldnt be used for cooking, like other types of cooking oil. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. D'Anchise, R., Bulitta, M., and Giannetti, B. Comfrey extract ointment in comparison to diclofenac gel in the treatment of acute unilateral ankle sprains (distortions). When buying commercial brands, seek those that have had the pyrrolizidine alkaloids removed, if possible. All rights reserved. Nutrition C for FS and A. Poisons Legislation Circular 3-22-1993;60. Browse our Sports Hub, Get 20% student discount with Student Beans, Discover the latest natural beauty products, Buy 1 get 1 Half Price on Vitamins & Supplements, Popular Vitamins & Supplements Subscriptions, Buy 1 get 1 Half Price gut health supplements, Guide to sleeping better natural sleeping remedies, Living in the now, gut health & mental wellbeing, The thing that makes you different makes you special, For the symptomatic relief of minor sprains and bruises, Contains Comfrey which is known for its healing properties. Facebook; Twitter; Pinterest; Related Posts. Ther Drug Monit 2001;23:698-708. Kucera, M., Barna, M., Horacek, O., Kovarikova, J., and Kucera, A. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Discard after a year or according to labeling. Nat Prod Res 2018;32(5):605-9. doi: 10.1080/14786419.2017.1326492. You and your healthcare provider should weigh the pros and cons and use it only under their supervision. Jurcu, R., & Jurcu, I. Heat oil in double boiler gently then add beeswax until it melts. Avoid using comfrey extracts on broken skin or open wounds. Comfrey has been claimed to heal gastric ulcers and hemorrhoids, and to suppress bronchial congestion and inflammation. Need some help with an order or want to speak to a member of our Customer Services team? Allow the oil mixture to cool until it reaches room temperature, which could take 8-12 hours. Megan Nunn, PharmD, is a community pharmacist in Tennessee with over twelve years of experience in medication counseling and immunization. For that reason, Ive also included my go-to comfrey cream recipe for achy joints and muscles! Mackinnon, M. In general practice, 'always expect the unexpected'. Registered office: Samuel Ryder House, Barling Way, Nuneaton, Warwickshire CV10 7RH. The use of babosa (Aloe vera) in treating burns: a literature review. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. When harvesting comfrey or buying from a non-commercial supplier, note that there is variety within the species. Here's a look at research on comfrey cream for back pain, osteoarthritis, and ankle sprains. Children, who suffer from these injuries the most, are statistically unlikely to have adverse reactions to comfrey oil when used on scrapes.5, When comfrey was applied topically to animals above where theyd suffered bone fractures, their bones healed at a much-improved rate than animals who hadnt been treated with comfrey.6, Leg ulcers are uncomfortable, prone to infection, and can take a long time to heal. Whether youve been hiking, biking, playing, or enjoying water sports, comfrey cream can be a wonderful ally in supporting achy muscles that result from physical, summertime activities. 2007;14(1):2-10. Available for Android and iOS devices. , meaning to grow together. This recipe is contraindicated for small children and those with certain medical conditions. Symphytum species: A comprehensive review on chemical composition, food applications and phytopharmacology. Since these toxic substances can be absorbed through the skin, there's concern about the safety of comfrey cream applied topically. *PR sample. The way that they work is by blocking small blood vessels in the liver. Glass bowl with a lid J Chin Med.Assoc. Credit Solution Experts Incorporated offers quality business credit building services, which includes an easy step-by-step system designed for helping clients build their business credit effortlessly. Comfrey root: from tradition to modern clinical trials, Efficacy and safety of comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo-controlled, multicentre trial, Topical herbal therapies for treating osteoarthritis, Effect of a blend of comfrey root extract (Symphytum officinale L.) and tannic acid creams in the treatment of osteoarthritis of the knee: randomized, placebo-controlled, double-blind, multiclinical trials, Treatment with 4Jointz reduces knee pain over 12 weeks of treatment in patients with clinical knee osteoarthritis: a randomised controlled trial. It also came as a reference to the belief that comfrey can mend broken bones. . 1. Nyman) in children: A randomized double-blind study. Latest: Senior Software Engineer - Front End Senior Software Engineer Senior Product Manager - Basket, Checkout and Payments UX Designer - Instore Tech. Spine(Phila Pa 1976). 2012;26(10):14411448. Comfrey shouldn't be used in any form during pregnancy or nursing due to the risk of liver damage to infants. Phytother Res. Stam, C., Bonnet, M. S., & van Haselen, R. A. Further study is needed to confirm these results. We comply with the HONcode standard for trustworthy health information. Additionally, use on a deep cut may encourage healing of the outer skin the preparation comes in direct contact with faster than the deeper tissue, leading to abscess. 1 Since at least the 4 th century, people have used comfrey medicinally. Swiss.Med.Wkly. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: Results of a double-blind, randomised, bicenter, placebo-controlled trial.
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